import os import subprocess # Set an environment variable in the parent process os.environ["PARENT_VARIABLE"] = "12345s" # Spawn a subprocess and modify the environment variable subprocess.run( [ "python", "-c", "import os; print('b', os.environ['PARENT_VARIABLE']); os.environ['PARENT_VARIABLE'] = 'modified_value'; print('c', os.environ['PARENT_VARIABLE'])", ] ) # Check if the modification in the subprocess affected the parent process print("a", os.environ["PARENT_VARIABLE"]) # This will print 'parent_value', not 'modified_value'